To Bind or Not to Bind: Unravelling GPCR Polypharmacology.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29425482.
- Also identified by DOI 10.1016/j.cell.2018.01.018.
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Abstract
Interaction of a single drug with multiple targets through "polypharmacology" is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues for drug development.
Medical subject headings
- Dopamine
- Polypharmacology