Diastereoselective synthesis of chiral 1,3-cyclohexadienals.
basic_science · Level V
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- Record sourced from PubMed, PMID 29438416.
- Also identified by DOI 10.1371/journal.pone.0192113 and PMC identifier 5810990.
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Abstract
A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.
Medical subject headings
- Aldehydes
- Cyclohexenes