Targeting HSF1: A Prime Integrator of Proteotoxic Stress Response in Myeloma.
editorial · Level V
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- Record sourced from PubMed, PMID 29440176.
- Also identified by DOI 10.1158/1078-0432.CCR-18-0030.
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Abstract
The HSF1 transcription factor is an integrator of the cellular stress response, and its expression has demonstrated poor prognosis in multiple myeloma. The novel anti-HSF1 small-molecule inhibitors CCT251236 and KRIB11 demonstrate <i>in vitro</i> and <i>in vivo</i> antimyeloma activity, representing a novel approach for targeting the heat shock response in myeloma. <i>Clin Cancer Res; 24(10); 2237-8. ©2018 AACR</i><i>See related article by Fok et al., p. 2395</i>.
Medical subject headings
- Multiple Myeloma