Association between acute respiratory disease events and the <i>MUC5B</i> promoter polymorphism in smokers.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 29440587.
- Also identified by DOI 10.1136/thoraxjnl-2017-211208 and PMC identifier 6089672.
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Abstract
A single-nucleotide polymorphism (rs35705950) in the mucin 5B (<i>MUC5B</i>) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the <i>MUC5B</i> promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The <i>MUC5B</i> promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.
Medical subject headings
- DNA
- Genetic Predisposition to Disease
- Mucin-5B
- Polymorphism, Single Nucleotide
- Respiratory Tract Diseases
- Smokers
- Smoking