EANM guidelines for radionuclide therapy of bone metastases with beta-emitting radionuclides.

Handkiewicz-Junak, Daria; Poeppel, Thorsten D; Bodei, Lisa; Aktolun, Cumali; Ezziddin, Samer; Giammarile, Francesco; Delgado-Bolton, Roberto C; Gabriel, Michael · Eur J Nucl Med Mol Imaging · 2018

review · Level V

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Abstract

The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a major healthcare problem in patients with bone metastases. Bone-seeking radionuclides that selectively accumulate in the bone are used to treat cancer-induced bone pain and to prolong survival in selected groups of cancer patients. The goals of these guidelines are to assist nuclear medicine practitioners in: (a) evaluating patients who might be candidates for radionuclide treatment of bone metastases using beta-emitting radionuclides such as strontium-89 (<sup>89</sup>Sr), samarium-153 (<sup>153</sup>Sm) lexidronam (<sup>153</sup>Sm-EDTMP), and phosphorus-32 (<sup>32</sup>P) sodium phosphate; (b) performing the treatments; and

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