Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29455516.
- Also identified by DOI 10.1021/acsnano.7b08152 and PMC identifier 6037424.
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Abstract
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core-shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel. Importantly, the H<sub>2</sub>O<sub>2</sub>-responsive microneedles are coated with a thin-layer embedding H<sub>2</sub>O<sub>2</sub>-scavenging enzyme, thus mimicking the complementary function of enzymes in peroxisomes to protect normal tissues from injury caused by oxidative stress. Utilizing a chemically induced type 1 diabetic mouse model, we demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility.
Medical subject headings
- Delayed-Action Preparations
- Diabetes Mellitus, Type 1
- Drug Delivery Systems
- Hydrogels
- Hydrogen Peroxide
- Hypoglycemic Agents
- Insulin