Antibiotic Resistance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29474914.
- Also identified by DOI 10.1016/j.cell.2018.02.018.
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Abstract
Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.
Medical subject headings
- Drug Resistance, Bacterial