The Unexpected Effects of the Combination of Antibiotics and Immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29474916.
- Also identified by DOI 10.1016/j.cell.2018.02.003.
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Abstract
β-lactam antibiotics and immune enzymes, including lysozyme, kill bacteria by rupturing the cell wall. Curiously, their combination can select for viable, wall-less bacteria. Kawai and colleagues describe the molecular details regarding the emergence of these forms, illustrating a novel and potentially clinically relevant mechanism by which bacteria escape killing by antibiotics.
Medical subject headings
- Anti-Bacterial Agents
- beta-Lactams