IgA nephropathy: toward more specific diagnosis (and rescue of snails).
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29475546.
- Also identified by DOI 10.1016/j.kint.2017.10.028.
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Abstract
The diagnosis of IgA nephropathy relies on the histologic demonstration of glomerular mesangial IgA deposits. However, only a very small fraction of IgA, namely, galactose-deficient IgA1, seems to induce the disease. So far, this type of IgA could only be detected using mass spectrometry or lectins, which are relatively difficult to standardize. A novel monoclonal antibody, KM55, specifically recognizing galactose-deficient IgA1, may now change this.
Medical subject headings
- Glomerulonephritis, IGA
- Immunoglobulin A