α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 2.
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- Record sourced from PubMed, PMID 29496984.
- Also identified by DOI 10.2967/jnumed.117.204651 and PMC identifier 6910645.
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Abstract
The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies.
Medical subject headings
- Alpha Particles
- Radiochemistry
- Translational Research, Biomedical