Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29499143.
- Also identified by DOI 10.1016/j.stem.2018.01.019.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.
Medical subject headings
- Neural Stem Cells
- Succinic Acid