Parallelization of MAFFT for large-scale multiple sequence alignments.
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- Record sourced from PubMed, PMID 29506019.
- Also identified by DOI 10.1093/bioinformatics/bty121 and PMC identifier 6041967.
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Abstract
SUMMARY: We report an update for the MAFFT multiple sequence alignment program to enable parallel calculation of large numbers of sequences. The G-INS-1 option of MAFFT was recently reported to have higher accuracy than other methods for large data, but this method has been impractical for most large-scale analyses, due to the requirement of large computational resources. We introduce a scalable variant, G-large-INS-1, which has equivalent accuracy to G-INS-1 and is applicable to 50 000 or more sequences. AVAILABILITY AND IMPLEMENTATION: This feature is available in MAFFT versions 7.355 or later at https://mafft.cbrc.jp/alignment/software/mpi.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology
- Sequence Alignment
- Software