High Cholesterol at the Heart of Phagolysosomal Damage.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29514061.
- Also identified by DOI 10.1016/j.cmet.2018.02.015.
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Abstract
Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.
Medical subject headings
- Remyelination