PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix.
basic_science · Level V
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- Record sourced from PubMed, PMID 29514181.
- Also identified by DOI 10.1093/bioinformatics/bty127 and PMC identifier 6041753.
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Abstract
Transcription factors regulate gene expression by binding to specific short DNA sequences of 5-20 bp to regulate the rate of transcription of genetic information from DNA to messenger RNA. We present PWMScan, a fast web-based tool to scan server-resident genomes for matches to a user-supplied PWM or transcription factor binding site model from a public database. The web server and source code are available at http://ccg.vital-it.ch/pwmscan and https://sourceforge.net/projects/pwmscan, respectively. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genomics
- Position-Specific Scoring Matrices
- Regulatory Sequences, Nucleic Acid
- Software
- Transcription Factors