A new era of rationally designed antipsychotics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29517027.
- Also identified by DOI 10.1038/d41586-018-02328-z and PMC identifier PMC5624946.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The ideal drugs for treating schizophrenia are postulated to selectively block the D2 dopamine receptor with optimum binding kinetics. The structure of D2 bound to an antipsychotic sheds light on how to design such drugs.