Method for identification of condition-associated public antigen receptor sequences.
Where this comes from
- Record sourced from PubMed, PMID 29533178.
- Also identified by DOI 10.7554/eLife.33050 and PMC identifier 5873893.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR[Formula: see text] sequences .
Medical subject headings
- Adaptive Immunity
- Diabetes Mellitus
- Receptors, Antigen
- Receptors, Antigen, T-Cell