Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy.
case_control · Level III
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- Record sourced from PubMed, PMID 29537656.
- Also identified by DOI 10.1002/ana.25211 and PMC identifier 5912971.
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Abstract
We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE<sub>1</sub> ). We analyze PTE<sub>1</sub> risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE<sub>1</sub> (odds ratio [OR], 3.16 [0.99, 11.68]); subdural hematoma is another independent risk factor (OR, 4.13 [1.18, 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest that increased EA prevalence identifies patients at increased risk for PTE<sub>1</sub> , and that EAs acutely post-TBI can identify patients most likely to benefit from antiepileptogenesis drug trials. Ann Neurol 2018;83:858-862.
Medical subject headings
- Brain Injuries, Traumatic
- Brain Waves
- Epilepsy, Post-Traumatic