α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 1.
basic_science · Level V
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- Record sourced from PubMed, PMID 29545378.
- Also identified by DOI 10.2967/jnumed.116.186338 and PMC identifier 6004557.
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Abstract
With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.
Medical subject headings
- Alpha Particles
- Radiochemistry