Pathological Cerebrospinal Fluid Findings in Patients With Neuralgic Amyotrophy and Acute Hepatitis E Virus Infection.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 29547884.
- Also identified by DOI 10.1093/infdis/jiy128.
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Abstract
There is growing evidence that hepatitis E virus (HEV) infection can present with extrahepatic manifestations including neurological disorders. Among these, neuralgic amyotrophy (NA) has been reported to occur in some industrialized countries. We investigated 35 patients with NA and a control group for markers of HEV infection. Acute HEV infection was found in NA patients only and was associated with an inflammatory response in the central nervous system. Shedding of HEV RNA into the cerebrospinal fluid and intrathecal production of anti-HEV immunoglobulin M occurred in 1 patient, suggesting that HEV is neurotropic.
Medical subject headings
- Brachial Plexus Neuritis
- Cerebrospinal Fluid
- Hepatitis E
- Hepatitis E virus