Clinical features of patients with diabetic anterior uveitis.

Abstract

To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus. Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center. Ocular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%). Seven cases were bilateral. Intraocular pressure >21 mm Hg (7 eyes, 28%) and diabetic retinopathy (7 eyes, 28%, all non-proliferative) were also noted. The mean random blood glucose was 332 mg/dL (range 135-604 mg/dL) and the mean haemoglobin A1c was 12.6% (range 9.7%-16.7%). Seven patients (39%) were unaware of their hyperglycaemic state, and the remainder had either poor glucose control or had discontinued their diabetes treatment. Systemic examination and ancillary testing ruled out other possible causes of the uveitis. The ocular inflammation was managed in all cases using local corticosteroid therapy (drops and subconjunctival injections) in addition to internal medicine intervention for the diabetes. The best-corrected visual acuity (BCVA) was improved or maintained in all eyes at 3 months. The BCVA was ≤0.5 in two eyes due to both cataract and diabetic macular oedema. We characterised new-onset anterior uveitis in 18 patients in association with poorly controlled or undiagnosed diabetes mellitus. The uveitis was managed in all cases with local corticosteroid therapy in addition to proper diabetes systemic treatment.