Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 29563502.
- Also identified by DOI 10.1038/s41467-018-03258-0 and PMC identifier 5862842.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p < 5 × 10<sup>-8</sup>) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease.
Medical subject headings
- Growth Differentiation Factor 15
- Hyperemesis Gravidarum
- Insulin-Like Growth Factor Binding Proteins
- Nausea
- Placenta
- Pregnancy Complications
- Vomiting