Nondegradable magnetic poly (carbonate urethane) microspheres with good shape memory as a proposed material for vascular embolization.

Abstract

In this study, nondegradable poly (carbonate urethane) (PCU) and poly (carbonate urethane) incorporated variable Fe₃O₄ content microspheres (PCU/Fe₃O₄) were synthesized using pre-polymerization and suspension polymerization. Synthesis was confirmed through Fourier transform infrared spectroscopy (FTIR). The effect of Fe₃O₄ incorporation was investigated on crystalline, thermal, shape memory and degradation properties by X-Ray diffraction (XRD), Differential scanning calorimetery (DSC), compression test and degradation in vitro, respectively. Otherwise, the assessment of magnetic characteristics by vibrational sample magnetometry (VSM) disclosed superparamagnetic behavior. The tunable superparamagnetic behavior depends on the amount of magnetic particles incorporated within the networks. The biological study results of as-synthesized polymers from the platelet adhesion test and the cell proliferation inhibition test indicated they were biocompatible in vitro. Fe₃O₄ incorporation was conductive to reducing platelet adhesion in blood contacting test and promotion of rat vascular smooth muscle cell proliferation and growth. These nondegradable, superparamagnetic, biocompatible polymers, combined with their good shape memory properties may allow for their future exploitation in the biomedical field, such as, in cardiovascular implants, targeted tumor treatment, tissue engineering and artificial organ's engineering.