Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29570991.
- Also identified by DOI 10.1016/j.cell.2018.03.014 and PMC identifier 6014618.
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Abstract
The construction of a predictive model of an entire eukaryotic cell that describes its dynamic structure from atomic to cellular scales is a grand challenge at the intersection of biology, chemistry, physics, and computer science. Having such a model will open new dimensions in biological research and accelerate healthcare advancements. Developing the necessary experimental and modeling methods presents abundant opportunities for a community effort to realize this goal. Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic β-cell, a relevant target for understanding and modulating the pathogenesis of diabetes.
Medical subject headings
- Insulin-Secreting Cells
- Models, Biological