Metazoan MicroRNAs.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29570994.
- Also identified by DOI 10.1016/j.cell.2018.03.006 and PMC identifier 6091663.
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Abstract
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.
Medical subject headings
- MicroRNAs