Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics.
basic_science · Level V
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- Record sourced from PubMed, PMID 29577576.
- Also identified by DOI 10.1002/jbm.a.36400 and PMC identifier 6093774.
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Abstract
Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self-assembly of poly(glycerol sebacate)-co-poly(ethylene glycol) (PGS-co-PEG). The PGS-PEG nanoparticle system is highly tunable, and the semiaxis length of the nanoparticles can be modulated by changing PGS-PEG molar ratio and incorporating therapeutics. As both PGS and PEG are highly biocompatible, the PGS-co-PEG nanoparticles show high hemo-, immuno-, and cytocompatibility. Our data suggest that PGS-co-PEG nanoparticles have the potential for use in a wide range of biomedical applications including regenerative medicine, stem cell engineering, immune modulation, and cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2048-2058, 2018.
Medical subject headings
- Decanoates
- Drug Delivery Systems
- Glycerol
- Nanoparticles
- Polyethylene Glycols
- Polymers