Photoactivatable drugs for nicotinic optopharmacology.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29578537.
- Also identified by DOI 10.1038/nmeth.4637 and PMC identifier 5923430.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of available compounds is limited. We describe a general method for caging tertiary amines by using a stable quaternary ammonium linkage that elicits a red shift in the activation wavelength. We prepared a photoactivatable nicotine (PA-Nic), uncageable via one- or two-photon excitation, that is useful to study nicotinic acetylcholine receptors (nAChRs) in different experimental preparations and spatiotemporal scales.
Medical subject headings
- Nicotine
- Photochemical Processes
- Receptors, Nicotinic