Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 29579256.
- Also identified by DOI 10.1093/infdis/jiy071 and PMC identifier 6065500.
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Abstract
This report describes the identification of a genetically confirmed linked heterosexual human immunodeficiency virus (HIV) superinfection (HIV-SI) in a woman with chronic HIV infection who acquired a second strain of the virus from her husband. Serum neutralizing antibody (NAb) responses against their homologous and heterologous viruses, including the superinfecting strain, in the woman and her husband were examined before and after onset of HIV-SI. The woman displayed a moderately potent and broad anti-HIV NAb response prior to superinfection but did not possess NAb activity against the superinfecting strain. This case highlights the unique potential of linked HIV-SI studies to examine natural protection from HIV infection.
Medical subject headings
- Antibodies, Neutralizing
- Antibody Formation
- HIV Antibodies
- HIV Infections
- HIV-1
- Superinfection