Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29580841.
- Also identified by DOI 10.1016/j.ebiom.2018.03.010 and PMC identifier 5952343.
- Licence recorded as CC BY-NC-ND.
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Abstract
Long non-coding RNAs (lncRNAs) belong to a recently discovered class of molecules proposed to regulate various cellular processes. Here, we systematically analyzed their expression in human subcutaneous white adipose tissue (WAT) and found that a limited set was differentially expressed in obesity and/or the insulin resistant state. Two lncRNAs herein termed adipocyte-specific metabolic related lncRNAs, ASMER-1 and ASMER-2 were enriched in adipocytes and regulated by both obesity and insulin resistance. Knockdown of either ASMER-1 or ASMER-2 by antisense oligonucleotides in in vitro differentiated human adipocytes revealed that both genes regulated adipogenesis, lipid mobilization and adiponectin secretion. The observed effects could be attributed to crosstalk between ASMERs and genes within the master regulatory pathways for adipocyte function including PPARG and INSR. Altogether, our data demonstrate that lncRNAs are modulators of the metabolic and secretory functions in human fat cells and provide an emerging link between WAT and common metabolic conditions.
Medical subject headings
- Adipose Tissue, White
- Quantitative Trait, Heritable
- RNA, Long Noncoding