Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29581484.
- Also identified by DOI 10.1038/s41467-018-03534-z and PMC identifier 5964314.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The sequenced Diels-Alder/oxidation reaction represents a powerful route for the construction of aromatic compounds in organic synthesis. The oxidative Diels-Alder reaction with H<sub>2</sub> evolution would be a more ideal approach that can avoid the additional oxidation procedure and stoichiometric oxidant. Herein, an oxidative [4 + 2] annulation reaction of styrene derivatives with electron-rich dienophiles accompanying the H<sub>2</sub> generation has been developed by using the synergistic merger of photoredox and cobaloxime catalyst. With respect to atom and step-economy ideals, this dual catalytic system enables the formation of high-value molecules from feedstock chemicals in a single step under room temperature.