π-Extended Benzoporphyrin-Based Metal-Organic Framework for Inhibition of Tumor Metastasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 29584395.
- Also identified by DOI 10.1021/acsnano.8b01186.
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Abstract
We report on the benzoporphyrin-based metal-organic framework (TBP-MOF), with 10-connected Zr<sub>6</sub> cluster and much improved photophysical properties over the traditional porphyrin-based MOFs. It was found that TBP-MOF exhibited red-shifted absorption bands and strong near-infrared luminescence for bioimaging, whereas the π-extended benzoporphyrin-based linkers of TBP-MOF facilitated <sup>1</sup>O<sub>2</sub> generation to enhance O<sub>2</sub>-dependent photodynamic therapy (PDT). It was demonstrated that poly(ethylene glycol)-modified nanoscale TBP-MOF (TBP-nMOF) can be used as an effective PDT agent under hypoxic tumor microenvironment. We also elucidated that the low O<sub>2</sub>-dependent PDT of TBP-nMOF in combination with αPD-1 checkpoint blockade therapy can not only suppress the growth of primary tumor, but also stimulate an antitumor immune response for inhibiting metastatic tumor growth. We believe this TBP-nMOF has great potential to serve as an efficient photosensitizer for PDT and cancer immunotherapy.
Medical subject headings
- Antineoplastic Agents
- Metal-Organic Frameworks
- Nanoparticles
- Neoplasm Metastasis
- Photosensitizing Agents
- Porphyrins
- Zirconium