A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 29596489.
- Also identified by DOI 10.1371/journal.pone.0195126 and PMC identifier 5875862.
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Abstract
Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.
Medical subject headings
- Aging
- Cell Physiological Phenomena
- Computational Biology
- Insulin-Like Growth Factor I
- Wnt Signaling Pathway