Preclinical Studies of Stem Cell Therapy for Heart Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29599277.
- Also identified by DOI 10.1161/CIRCRESAHA.117.312486 and PMC identifier 7340290.
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Abstract
As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.
Medical subject headings
- Cellular Reprogramming Techniques
- Heart Diseases
- Pluripotent Stem Cells
- Stem Cell Transplantation