pyNBS: a Python implementation for network-based stratification of tumor mutations.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 29608663.
- Also identified by DOI 10.1093/bioinformatics/bty186 and PMC identifier 6084608.
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Abstract
We present pyNBS: a modularized Python 2.7 implementation of the network-based stratification (NBS) algorithm for stratifying tumor somatic mutation profiles into molecularly and clinically relevant subtypes. In addition to release of the software, we benchmark its key parameters and provide a compact cancer reference network that increases the significance of tumor stratification using the NBS algorithm. The structure of the code exposes key steps of the algorithm to foster further collaborative development. The package, along with examples and data, can be downloaded and installed from the URL https://github.com/idekerlab/pyNBS.
Medical subject headings
- Mutation
- Neoplasms
- Software