B<sub>6</sub> and Bleeding: A Case Report of a Novel Vitamin Toxicity.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 29610166.
- Also identified by DOI 10.1542/peds.2017-2039 and PMC identifier 5877127.
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Abstract
Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B<sub>6</sub> metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosphate oxidase deficiency and mild hemophilia A, whose bleeding symptoms were exacerbated by the vitamin B<sub>6</sub> therapy essential for his epileptic disorder. This report expands the spectrum of known vitamin B<sub>6</sub> toxicity and demonstrates a need for vigilance in monitoring for bleeding symptoms in patients requiring pyridoxine or pyridoxal-5-phosphate supplementation.
Medical subject headings
- Hemophilia A
- Hemorrhage
- Pyridoxal Phosphate
- Seizures
- Vitamin B 6
- Vitamin B 6 Deficiency
- Vitamins