The Need for Neddylation: A Key to Achieving NED in Uveal Melanoma.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29610291.
- Also identified by DOI 10.1158/1078-0432.CCR-18-0020 and PMC identifier 6446562.
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Abstract
The ability of uveal melanoma cells to enter and exit dormancy plays a fundamental role in the development of metastatic disease. Neddylation blockade is a promising strategy to prolong tumor dormancy via impaired angiogenesis and prevent the establishment of metastases via elimination of cancer stem-like cells. <i>Clin Cancer Res; 24(15); 3477-9. ©2018 AACR</i><i>See related article by Jin et al., p. 3741</i>.
Medical subject headings
- Liver Neoplasms
- Melanoma
- Uveal Neoplasms