Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse.
Level V
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- Record sourced from PubMed, PMID 29617638.
- Also identified by DOI 10.1016/j.cmet.2018.03.009 and PMC identifier 7205594.
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Abstract
Cellular senescence is traditionally viewed as a permanent form of cell cycle arrest that restrains tumorigenesis. In a recent study in Nature, however, Milanovic et al. (2018) challenge this conventional view, showing that senescence can counterintuitively promote cancer stemness and tumor aggressiveness. This finding suggests that attacking senescence can be exploited in cancer therapy.
Medical subject headings
- Cellular Senescence
- Neoplasm Recurrence, Local