Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29618562.
- Also identified by DOI 10.1126/scitranslmed.aah5457.
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Abstract
Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.
Medical subject headings
- Myocytes, Cardiac
- Pluripotent Stem Cells