Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 29632299.
- Also identified by DOI 10.1038/s41467-018-03178-z and PMC identifier 5890276.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10<sup>-9</sup>, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10<sup>-8</sup>, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Medical subject headings
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma