Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 29657445.
- Also identified by DOI 10.1016/j.jor.2018.01.051 and PMC identifier 5895930.
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Abstract
The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA). Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome. Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA. Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
Anatomy
- hip