H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M158-66-Specific CD8+ T Cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 29659927.
- Also identified by DOI 10.1093/infdis/jiy218 and PMC identifier 6047425.
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Abstract
Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During >6 years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated 4 other amino acid substitutions. However, these did not affect M158-66-specific CTL activation.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Epitopes, T-Lymphocyte
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Viral Matrix Proteins