Body mass index, sitting time, and risk of Parkinson disease.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 29661903.
- Also identified by DOI 10.1212/WNL.0000000000005328 and PMC identifier 5902782.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures. We prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs). We identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m<sup>2</sup>. Results did not differ by sex. No association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.
Medical subject headings
- Body Mass Index
- Parkinson Disease
- Sitting Position