Predicting Influenza H3N2 Vaccine Efficacy From Evolution of the Dominant Epitope.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29672670.
- Also identified by DOI 10.1093/cid/ciy323.
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Abstract
We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and vaccine viruses based on amino acid substitutions in the dominant epitope. In 2016-2017, our model predicts 19% efficacy compared with 20% observed. This tool assists candidate vaccine selection by predicting human protection against circulating strains.
Medical subject headings
- Immunodominant Epitopes
- Influenza Vaccines
- Influenza, Human