Antigen Presentation Keeps Trending in Immunotherapy Resistance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29674509.
- Also identified by DOI 10.1158/1078-0432.CCR-18-0698 and PMC identifier 6050090.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Through a gain-of-function kinome screen, <i>MEX3B</i> was identified as a mediator of resistance to T-cell immunotherapy not previously identified using CRISPR-based screens. MEX3B is a posttranscriptional regulator of HLA-A, validating the critical role of tumor-intrinsic antigen presentation in T-cell immunotherapy and indicating a new putative molecular target. <i>Clin Cancer Res; 24(14); 3239-41. ©2018 AACR</i><i>See related article by Huang et al., p. 3366</i>.
Medical subject headings
- Antigen Presentation
- Neoplasms