Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29677504.
- Also identified by DOI 10.1016/j.cell.2018.03.077.
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Abstract
Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.
Medical subject headings
- Carcinoma, Renal Cell
- Mutation