A Mechanosensitive GPCR that Detects the Bloody Force.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29677505.
- Also identified by DOI 10.1016/j.cell.2018.04.001 and PMC identifier 6706248.
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Abstract
Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.
Medical subject headings
- Mechanoreceptors
- Touch