Beyond the Transport Function of Import Receptors: What's All the FUS about?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29677508.
- Also identified by DOI 10.1016/j.cell.2018.04.002 and PMC identifier 7611746.
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Abstract
Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.
Medical subject headings
- Active Transport, Cell Nucleus
- Karyopherins
- RNA-Binding Protein FUS