Unraveling the mechanisms of obesity-induced hyperoxaluria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29680019.
- Also identified by DOI 10.1016/j.kint.2018.01.012 and PMC identifier 5972550.
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Abstract
Kidney stones is increasingly associated with obesity. With an increasing prevalence of obesity and metabolic syndrome in the past 30 years, urinary oxalate has significantly increased. However, its underlying pathophysiologic mechanisms of hyperoxaluria have not been fully explored. This preclinical study suggests that hyperoxaluria in obesity depends on a complex network of inflammatory responses linked to metabolic outcome. The future mechanistic and clinical investigations must be targeted at elucidating the pathogenetic role of inflammation in obesity induced hyperoxaluria.
Medical subject headings
- Hyperoxaluria
- Kidney Calculi