Correlates of Protection Against SIV<sub>mac251</sub> Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29685793.
- Also identified by DOI 10.1016/j.ebiom.2018.02.025 and PMC identifier 6013748.
- Licence recorded as CC BY-NC-ND.
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Abstract
We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)<sub>mac239</sub> tested in HAdV-seropositive rhesus macaques (RMs) repeatedly challenged rectally with low doses of SIV<sub>mac251.</sub> Both vaccine regimens reduced set point and peak viral loads (PVL) and accelerated viral clearance. In SAdV-vaccinated controller genotype RMs resistance against infection correlated with levels of envelope (Env)-specific antibody (Ab) titers. In both vaccine groups CD8<sup>+</sup>T cells controlled viral loads (VL) upon infection. Circulating CD4<sup>+</sup> and CD8<sup>+</sup> T cells showed significant changes in their transcriptome over time following vaccination, which differed between the vaccine groups. T cells from SIV-resistant RMs had unique transcriptional profiles indicating that both follicular T helper (T<sub>FH</sub>) cell responses and highly activated CD8<sup>+</sup> T cells may play a role in protection.
Medical subject headings
- Adenoviridae
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Gene Products, env
- Genetic Vectors
- Immunity, Cellular
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus