RANGER-DTL 2.0: rigorous reconstruction of gene-family evolution by duplication, transfer and loss.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29688310.
- Also identified by DOI 10.1093/bioinformatics/bty314 and PMC identifier 6137995.
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Abstract
RANGER-DTL 2.0 is a software program for inferring gene family evolution using Duplication-Transfer-Loss reconciliation. This new software is highly scalable and easy to use, and offers many new features not currently available in any other reconciliation program. RANGER-DTL 2.0 has a particular focus on reconciliation accuracy and can account for many sources of reconciliation uncertainty including uncertain gene tree rooting, gene tree topological uncertainty, multiple optimal reconciliations and alternative event cost assignments. RANGER-DTL 2.0 is open-source and written in C++ and Python. Pre-compiled executables, source code (open-source under GNU GPL) and a detailed manual are freely available from http://compbio.engr.uconn.edu/software/RANGER-DTL/. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology
- Evolution, Molecular
- Gene Duplication
- Software