Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29688635.
- Also identified by DOI 10.1002/adhm.201701357.
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Abstract
Photodynamic therapy (PDT) still faces two main problems on cancer therapy. One is how to improve PDT efficiency against hypoxic environment of tumors. The other one is how to overcome the limit of short wavelength light to increase PDT treatment depth. In this work, an intraparticle fluorescence resonance energy transfer (FRET) platform is designed to address these problems together. The nanoparticles are doped with multicomponents, such as catalase, two-photon dyes, and traditional photosensitizers, with a simple "one-pot" and green method. On the one hand, catalase can catalyze intracellular H<sub>2</sub> O<sub>2</sub> into O<sub>2</sub> and promote PDT efficiency. One the other hand, photosensitizers can be excited indirectly by two-photon lasers through an intraparticle FRET mechanism, which results in deeper tissue penetration for PDT. These properties are verified through the material induced cytotoxicity in light or in dark and in vivo blocking blood-vessel experiment.
Medical subject headings
- Fluorescence Resonance Energy Transfer
- Nanoparticles
- Neoplasms
- Photochemotherapy
- Photosensitizing Agents